{"id":857,"date":"2020-04-15T18:46:28","date_gmt":"2020-04-15T16:46:28","guid":{"rendered":"https:\/\/www.irbm.com\/?p=8843"},"modified":"2020-08-21T15:18:09","modified_gmt":"2020-08-21T13:18:09","slug":"coffee-break-interview-with-piero-di-lorenzo-la7-15th-april","status":"publish","type":"post","link":"https:\/\/www.cnccs.it\/en\/2020\/04\/15\/coffee-break-interview-with-piero-di-lorenzo-la7-15th-april\/","title":{"rendered":"Coffee Break, interview with Piero Di Lorenzo &#x25aa; La7 \u2013 15th April"},"content":{"rendered":"<iframe loading=\"lazy\" title=\"Coffee Break, interview with Piero Di Lorenzo - La7 - 15th April\" width=\"1220\" height=\"686\" src=\"https:\/\/www.youtube.com\/embed\/kVjUAZVZgVQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">Right Claudia, I just need to ask you to be patient for a moment because next up I have Paolo Sottocorona and the commercial break, and then I want to talk to the man of the moment, as I see him, Piero Di Lorenzo from IRBM. The question everyone is asking Mr. Di Lorenzo, publicly and privately is: \u201cMr. Di Lorenzo, is there a vaccine against coronavirus, yes or no?\u201d<\/p>\n<p>DI LORENZO<\/p>\n<p style=\"text-align: justify;\">The answer is fairly straightforward: there is a vaccine, the candidate vaccine, and the response from the pre-clinical phase of laboratory testing is definitely positive. So positive in fact, that the British regulatory authority is minded to, and has been moving forwards, drastically reducing the timescales for testing. Consequently, by the end of the month, we will be sending the first batch of vaccine to Oxford and in the meantime they are already recruiting 550 healthy volunteers. This means we will be virtually ready for clinical phase 3, the final clinical phase. As for the timescales: we are hopeful that vaccinations can start by end of May, early June, and that we will have a response from the vaccination of these healthy volunteers as early as the end of September. Then I will tell you afterwards what you want to know \u2026 So you can go ahead with the commercial break.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">Yes, then we\u2019ll go into more detail, obviously.<\/p>\n<p style=\"text-align: justify;\">In the meantime, let\u2019s hope Professor Antinori arrives. Meanwhile, let\u2019s go to Paolo.<\/p>\n<p style=\"text-align: justify;\">Soon we will go back to Piero Di Lorenzo and the vaccine for coronavirus, let\u2019s see if we now have Professor Antinori on the line. Let\u2019s see if we have a good connection. Good morning and welcome back Professor.<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">Good morning to you.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">Excuse me, let me quickly ask you one thing. You lost the thread but you are well informed on this matter. We were speaking before with Piero Di Lorenzo, the CEO of IRBM in Pomezia; as you know they are developing a vaccine for coronavirus, you were telling us something earlier. Should we take this as good news or not Professor Antinori?<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">It certainly is good news, I mean, everything that is being done and all the work that is being developed by the scientists to ensure that a vaccine is produced that will, let\u2019s be honest, be the only real definitive solution to this issue, I\u2019d say that it\u2019s excellent news in any case.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">I want to ask you another thing, because there is an endless debate going on here which I understand is also very complex. With regard to lifting the lockdown, the scientists and the experts disagree to some extend about this too. We have understood, for example, that wearing a mask is essential, we have understood that social distancing is essential, but perhaps we have understood something else and so my question is this: can we only really lift the lockdown when the intensive care wards and hospital system overall are less congested? That way, if there were new and sudden outbreaks, we\u2019d be ready to react?<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">I would definitely say so. This is something very important. I wouldn\u2019t underestimate also the fall in the number of new infections, because in order to get to the point of lifting the lockdown, we need greater certainty about what is going on with the epidemic, i.e. how many new transmissions, how many new cases there are. To be honest, at the moment, I see a lot more work needing to be done in this respect.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">But shouldn\u2019t the regions take some responsibility for this? I\u2019m asking whether there is an open debate about this too. For example, Professor Rezza, from the National Health Institute has said: \u201cThe Regions must provide us with much more information, otherwise we can\u2019t get a complete and comparable picture.\u201d<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">I don\u2019t want to get into these issues which are typical of the relationship between the State and the Regions. I think that the comment that could be made by someone with a technical background, like myself, is that there should be maximum cooperation between the various organizations. The health care system today has been decentralized to regional level for many years, the State retains certain prerogatives. This epidemic has taught us that centralization is still a very important aspect, as is coordination between the various powers within the whole government of the country. I think the principle of collaboration is fundamental.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">But let me ask you something, because it is something of a more political nature but it directly involves experts as you are. Yesterday, in a long interview, Minister Boccia said: The scientific community must provide irrefutable certainties and not 3 or 4 options for each subject\u201d. He was saying, for example, that someone who has had the virus can get it again. Do we know whether the antibody tests are useful or not? Otherwise, according to the Minister, we don\u2019t have the knowledge. What do you say to that?<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">I think that is a strong statement which I personally do not agree with. I would like to remind everyone that this illness first appeared a little under two months ago, therefore I believe that in the history of medicine, there has never been another phenomenon that has produced so much research. There are already thousands of studies published on international databases and indexed listings of scientific journals, there has been an impressive mobilization of the whole international scientific community, within the space of a few weeks we have come up with highly developed diagnostic tools. A RT-PCR test is no ordinary test, it is an extremely important test which, in the case of other diseases, has been developed over a period of years. We have antibody tests, we have tested drugs, there are 25 drugs being studied, there are randomized studies taking place. Every day, the CTS at Aifa examines a dozen or so protocols. I don\u2019t\u2019 think we\u2019ve ever seen anything on this scale. Look, I had front line experience of the AIDS epidemic, over thirty years ago, I was a young doctor just starting out, I remember very clearly what happened then. I think that what we have seen with this illness, in terms of the scientific initiative is extraordinary, but we shouldn\u2019t think that science can come up with definitive answers within the space of a few weeks.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">You have been very clear, I want to go back for a moment to Piero Di Lorenzo, after which we\u2019ll also take up the finer political points of the discussion with both the Undersecretary Mrs. Guerra and Daniela Santanch\u00e8. Mr. Di Lorenzo, you were saying that we are ready to send a first batch of the vaccine to Oxford, so to the UK. But what does it mean? What about Italy?<\/p>\n<p>DI LORENZO<\/p>\n<p style=\"text-align: justify;\">This partnership came about in order to take advantage of 2 very important areas of expertise. The Jenner Institute is, I\u2019d say, the repository of very important knowledge about the family of coronaviruses, because it has already studied SARS, it has developed the anti-MERS vaccine and within a fortnight of the sequencing of the virus, they synthesized the gene of the Spike protein. Our expertise on the other hand, relates to the vehicle, the shuttle, which is the adenovirus that is used to insert the synthesized gene of the protein into the human body. It is therefore a very important collaboration. You need to bear 2 things in mind: the first is that all the operational and research funding comes from the CEPI, which is a supranational organization funded by the British, Dutch and Norwegian governments. So, as I was also saying to one of your colleagues yesterday evening, the ones who pay get to make the decisions. Then there is another thing: the Jenner Institute, which is in constant contact with the British regulatory authority, has managed to get these tests under way very quickly, which is something we are now preparing to do in Italy. So the whole thing first started in England. A am not ruling out anything; I have discussed this matter with Minister Manfredi and Minister Speranza, they are both very proactive on the subject. I should add that this is now being reviewed by the President so, as a country we are not holding back, in other words we are ready to take all possible initiatives. Bear in mind, I\u2019d like to underline this point; earlier I told you that the first batch will be leaving for Oxford at the end of April, the phase 3 tests on 550 healthy volunteers will get under way\u00a0 in June \u2026 we expect that by September there will be already be some significant and conclusive scientific\u00a0 evidence on the table. Let me be very clear though: this does not mean that by Christmas we will all be vaccinated. The thing is that once the tests are approved, hopefully, in the autumn, the vaccine will, I hope, be approved, and then there are the technical timescales to deal with. So, whilst the official approval is being processed, etc., the doses of vaccine that have been produced in the meantime will be available to be used on a compassionate basis. But then we need to move onto an industrial scale and there are technical timescales that cannot be shortened.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">How long? What are we looking at, how long, technically, does it take to produce in on a worldwide scale? How long will it take?<\/p>\n<ol style=\"text-align: justify;\">\n<li>DI LORENZO<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">In order to produce it on an industrial scale we are looking at the new year, we\u2019re talking spring next year; but don\u2019t forget that there are 8 billion people to cater for, no industry can say \u201cwe can make 8 billion doses of vaccine in a year\u201d.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">You have been very clear.<\/p>\n<p style=\"text-align: justify;\">CLAUDIA FUSANI<\/p>\n<p style=\"text-align: justify;\">I just want to make 2 short points. First of all, with regard to what Professor Antinori was saying, politicians must show courage now, because science can never give answers that are entirely precise or unequivocal. It\u2019s become a bit of a game, if I can use the term, and that isn\u2019t OK. At some point, politicians need to take a decision and show courage that\u2019s the first point. Secondly, with regard to the EMS, I am referring to the last discussion on vaccines. If released, this EMS would immediately give us 36 or 37 billion to invest directly or indirectly in healthcare. To rebuild in Italy the chemical and pharmaceutical supply chain for vaccines, serums \u2026 that we are lacking, because we dismantled it. That money should be used now because the Corona bond and the Recovery bond will be discussed months down the line. We need money right now, to rebuild the laboratories, we aren\u2019t able to make swabs because we don\u2019t have the reagents, that\u2019s because they are produced elsewhere. We have to bring that supply chain back to Italy.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">I want to end by talking to Mrs. Santanch\u00e8 and Undersecretary Mrs. Guerra. Undersecretary, I gather that Mr. Laforgia, who is a major figure in your party, has said that healthcare in Lombardy should be put under external administration. Do you really believe that? Is that what you are asking for?<\/p>\n<p style=\"text-align: justify;\">UNDERSECRETARY GUERRA<\/p>\n<p style=\"text-align: justify;\">Well, Mr. Laforgia is from Lombardy so his assessment will have been made on the basis of information that I do not have. I don\u2019t think there is a need to put it under external administration. We certainly have a problem generally with strengthening the network, the public health department in central government, so that the conditions for essential levels of care are guaranteed across the entire country. I think the Lombardy health model has its limitations, especially as regards its relationship with the private sector, which has perhaps been given too much room, but I am not personally in a position to back up this claim.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">I\u2019d like to hear from Daniela Santanch\u00e8 on this.<\/p>\n<p style=\"text-align: justify;\">DANIELA SANTANCH\u00c8<\/p>\n<p style=\"text-align: justify;\">Thank you, and thank you Undersecretary, because now I shall immediately issue a press release saying that companies with more than 5 employees don\u2019t need to notify the union to request funds from the business interruption scheme.<\/p>\n<p style=\"text-align: justify;\">UNDERSECRETARY GUERRA<\/p>\n<p style=\"text-align: justify;\">If they\u2019ve been closed by the Prime Ministerial Decree. I want to be clear about this,<\/p>\n<p style=\"text-align: justify;\">DANIELA SANTANCH\u00c8<\/p>\n<p style=\"text-align: justify;\">No, look<\/p>\n<p style=\"text-align: justify;\">UNDERSECRETARY GUERRA<\/p>\n<p style=\"text-align: justify;\">If they\u2019ve been closed by the Prime Ministerial Decree.<\/p>\n<p style=\"text-align: justify;\">DANIELA SANTANCH\u00c8<\/p>\n<p style=\"text-align: justify;\">I believe what you are now saying, I\u2019ll issue a press release right away because until now we hadn\u2019t understood a thing and I\u2019d remind you that I continue to make the claim, but thank you for refuting the fact, that companies with more than 15 employees don\u2019t have to send an electronic communication to the union and that there is no need to await a reply because it is done by default. This is a huge simplification. Today I\u2019ll say that you have made this very important clarification on air for which I thank you. As regards putting health care under external administration and the banks we\u2019ll see you again.<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">Of course we\u2019ll talk about it again, in the coming days! In facts, we will invite you as of now to come back again.<\/p>\n<p style=\"text-align: justify;\">DANIELA SANTANCH\u00c8<\/p>\n<p style=\"text-align: justify;\">Fine, see you next week. Hurray, hurray, the money is finally on its way, as I recall we\u2019ve been talking about it since March 6<sup>th<\/sup> no less and it\u2019s now April 15<sup>th<\/sup>.<\/p>\n<p style=\"text-align: justify;\">UNDERSECRETARY GUERRA<\/p>\n<p style=\"text-align: justify;\">These things aren\u2019t easy, nobody is saying it is easy to do, there\u2019s no point in using fake irony.<\/p>\n<p style=\"text-align: justify;\">DANIELA SANTANCH\u00c8<\/p>\n<p style=\"text-align: justify;\">Undersecretary, you have clarified certain things that I \u2026<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">I have to end there, you must excuse me but I have to wrap things up. There is no doubt that this situation is extremely difficult and that things are complicated and everyone has their own opinion on how the government is responding. But we\u2019ll back again with Undersecretary Guerra, with Daniela Santanch\u00e8. Thanks as always to Professor Antinori and our best wishes and thanks to everyone for the great work being done<\/p>\n<p style=\"text-align: justify;\">PROFESSOR ANTINORI<\/p>\n<p style=\"text-align: justify;\">Thanks and best wishes to you too<\/p>\n<p style=\"text-align: justify;\">ANDREA PANCANI<\/p>\n<p style=\"text-align: justify;\">At the Spallanzani Institute. I\u2019ll say goodbye to Piero Di Lorenzo, thank you and don\u2019t forget to give us the latest good news on the vaccine. Meanwhile it\u2019s over to Myrta. Hi Myrta.<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row]","protected":false},"excerpt":{"rendered":"<p>ANDREA PANCANI Right Claudia, I just need to ask you to be patient for a moment because next up I have Paolo Sottocorona and the commercial break, and then I want to talk to the man of the moment, as I see him, Piero Di Lorenzo from IRBM. The question everyone is asking Mr. Di &hellip;<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-857","post","type-post","status-publish","format-video","hentry","category-galleria","post_format-post-format-video"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Coffee Break, interview with Piero Di Lorenzo &#x25aa; La7 \u2013 15th April - CNCCS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cnccs.it\/en\/2020\/04\/15\/coffee-break-interview-with-piero-di-lorenzo-la7-15th-april\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coffee Break, interview with Piero Di Lorenzo &#x25aa; La7 \u2013 15th April - CNCCS\" \/>\n<meta property=\"og:description\" content=\"ANDREA PANCANI Right Claudia, I just need to ask you to be patient for a moment because next up I have Paolo Sottocorona and the commercial break, and then I want to talk to the man of the moment, as I see him, Piero Di Lorenzo from IRBM. 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