{"id":869,"date":"2020-03-13T18:46:04","date_gmt":"2020-03-13T17:46:04","guid":{"rendered":"https:\/\/www.irbm.com\/?p=8433"},"modified":"2020-07-23T19:39:48","modified_gmt":"2020-07-23T17:39:48","slug":"irbm-is-close-to-a-vaccine-tg-com-24-13th-march","status":"publish","type":"post","link":"https:\/\/www.cnccs.it\/en\/2020\/03\/13\/irbm-is-close-to-a-vaccine-tg-com-24-13th-march\/","title":{"rendered":"IRBM is close to a vaccine TG Com 24 \u2013 13th March"},"content":{"rendered":"[vc_row][vc_column][vc_video link=”https:\/\/youtu.be\/bzYYuzDHRRs”][\/vc_column][\/vc_row][vc_row][vc_column][vc_text_separator title=”ENGLISH TRANSCRIPT” color=”sky”][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]REPORTER<\/strong><\/p>\n

Good evening Piero Di Lorenzo, Molecular Biology Research Institute.<\/p>\n

You say you\u2019re very close to a vaccine, how close?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Good evening. Yes, very close, because, as I said in another interview, we have combined our expertise with that of Oxford University\u2019s Jenner Institute. They have…<\/p>\n

REPORTER<\/strong><\/p>\n

In the meantime we\u2019re just seeing images of your Institute and of the work you\u2019re doing. I\u2019m just saying this for the benefit of the people watching us of course. Go ahead.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Yes. As I was saying, Oxford University has great expertise in the Coronavirus family because it studied Sars for a long time and has developed and now tested the Mers vaccine. We have quite a major expertise, the platform to inoculate the human body with the modified gene we have synthetized, the one for the existing Coronavirus, which is Covid19.<\/p>\n

So we are quite optimistic that this vaccine will be effective and won\u2019t be toxic.<\/p>\n

We\u2019re going to start producing on Monday and we expect to make a thousand or so doses,<\/p>\n

which will be enough to…<\/p>\n

REPORTER<\/strong><\/p>\n

Now, Mr Di Lorenzo, I just want to understand this point. Next Monday you\u2019ll be able to produce a thousand or so doses, what does that mean?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Next Monday we\u2019re going to start producing the vaccine and we expect to have a thousand or so doses ready by May, which are sufficient for the trials on mice. By…<\/p>\n

REPORTER<\/strong><\/p>\n

How long do animal trials of the vaccine take?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

About a month. So by June we\u2019ll have started and will be well advanced in the trials on mice and we hope to move on to humans by the end of June.<\/p>\n

REPORTER<\/strong><\/p>\n

So can we just try to make the necessary procedures clear for someone who isn\u2019t an expert? You\u2019re saying that you\u2019ll be starting animal trials in May. In June, once these trials are over, if everything has gone well and is convincing and satisfactory, the human trials can begin, is that right?<\/p>\n

So what happens at that point?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

The trials on humans start on quite a small number of healthy volunteers, maybe 10, 12, 15 people, and at the end of this initial trial phase we\u2019ll move on to phase 2, when there will be 150\/200…<\/p>\n

REPORTER<\/strong><\/p>\n

How long does this trial take?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

According to the protocols and regulations, each of the three phases can take twelve to eighteen months.<\/p>\n

But clearly the times set by the regulations are the prescribed times.<\/p>\n

REPORTER<\/strong><\/p>\n

Yes, of course.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Not in the presence of such a contagious epidemic.<\/p>\n

REPORTER<\/strong><\/p>\n

In the presence of such a widespread, alarming and global epidemic, what kind of plausible and acceptable acceleration could there be, based on previous history?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

The process can be accelerated a very great deal.<\/p>\n

REPORTER <\/strong><\/p>\n

Meaning?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

I mean that if the effectiveness and non-toxicity can be demonstrated in animals,<\/p>\n

in the presence of a very dangerous epidemic which is, I dare say, out of control, national and international regulatory authorities can authorize the vaccine immediately.<\/p>\n

REPORTER<\/strong><\/p>\n

What would the risks be Mr Di Lorenzo? What would the risks be?<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

There is a whole discussion to be had about that.<\/p>\n

REPORTER<\/strong><\/p>\n

Let\u2019s summarize it.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Very briefly, one has to determine which is the lesser evil. Like any drug, vaccines can have side effects. The side effects are…<\/p>\n

REPORTER<\/strong><\/p>\n

This is behind the endless and fierce controversies there have been in recent months.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Precisely. I was referring to…<\/p>\n

REPORTER <\/strong><\/p>\n

In recent years, although, given the emergency, they aren\u2019t as fierce now…<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Yes, that\u2019s right…<\/p>\n

REPORTER<\/strong><\/p>\n

…And, I should point out, the fear caused by the Coronavirus.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

I want to stress that this is wrong… because it turns people into fans of one side or the other. It\u2019s wrong to say that there are no problems with vaccines. Like any drug, vaccines can and do have side effects. It\u2019s always important to apply the lesser evil principle. If a vaccine has a relatively minor side effect, in terms of the practical effect, and its extent, as a percentage, then…<\/p>\n

REPORTER<\/strong><\/p>\n

Very clear. Mr Di Lorenzo, you have been very clear. I\u2019d like to summarize further because we don\u2019t have an endless amount of time…<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Let\u2019s summarize it in a word: please, get vaccinated. For everything.<\/p>\n

REPORTER<\/strong><\/p>\n

Yes, but I wanted to summarize another point too. Of course, in that respect, I think many people can\u2019t wait for the vaccine. To summarize, let\u2019s say that by the end of June, end of July, we might already expect to be using a vaccine.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

Yes.<\/p>\n

REPORTER<\/strong><\/p>\n

Then it will be up to national and international authorities to say yes or no.<\/p>\n

PIERO DI LORENZO<\/strong><\/p>\n

If the regulatory authorities consider it useful, and can\u2019t see any contraindications, they can even start using it in July.[\/vc_column_text][\/vc_column][\/vc_row]","protected":false},"excerpt":{"rendered":"

vc_rowvc_columnvc_video link=”https:\/\/youtu.be\/bzYYuzDHRRs”\/vc_column\/vc_rowvc_rowvc_columnvc_text_separator title=”ENGLISH TRANSCRIPT” color=”sky”\/vc_column\/vc_rowvc_rowvc_columnvc_column_textREPORTER Good evening Piero Di Lorenzo, Molecular Biology Research Institute. You say you\u2019re very close to a vaccine, how close? PIERO DI LORENZO Good evening. Yes, very close, because, as I said in another interview, we have combined our expertise with that of Oxford University\u2019s Jenner Institute. They have… REPORTER In …<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-869","post","type-post","status-publish","format-video","hentry","category-galleria","post_format-post-format-video"],"yoast_head":"\nIRBM is close to a vaccine TG Com 24 \u2013 13th March - CNCCS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cnccs.it\/en\/2020\/03\/13\/irbm-is-close-to-a-vaccine-tg-com-24-13th-march\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRBM is close to a vaccine TG Com 24 \u2013 13th March - CNCCS\" \/>\n<meta property=\"og:description\" content=\"vc_rowvc_columnvc_video link=”https:\/\/youtu.be\/bzYYuzDHRRs”\/vc_column\/vc_rowvc_rowvc_columnvc_text_separator title=”ENGLISH TRANSCRIPT” color=”sky”\/vc_column\/vc_rowvc_rowvc_columnvc_column_textREPORTER Good evening Piero Di Lorenzo, Molecular Biology Research Institute. You say you\u2019re very close to a vaccine, how close? PIERO DI LORENZO Good evening. Yes, very close, because, as I said in another interview, we have combined our expertise with that of Oxford University\u2019s Jenner Institute. 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CNCCS","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cnccs.it\/en\/2020\/03\/13\/irbm-is-close-to-a-vaccine-tg-com-24-13th-march\/","og_locale":"en_US","og_type":"article","og_title":"IRBM is close to a vaccine TG Com 24 \u2013 13th March - CNCCS","og_description":"vc_rowvc_columnvc_video link=”https:\/\/youtu.be\/bzYYuzDHRRs”\/vc_column\/vc_rowvc_rowvc_columnvc_text_separator title=”ENGLISH TRANSCRIPT” color=”sky”\/vc_column\/vc_rowvc_rowvc_columnvc_column_textREPORTER Good evening Piero Di Lorenzo, Molecular Biology Research Institute. You say you\u2019re very close to a vaccine, how close? PIERO DI LORENZO Good evening. Yes, very close, because, as I said in another interview, we have combined our expertise with that of Oxford University\u2019s Jenner Institute. 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